Since joining Twitter back April of 2009, Oprah Winfrey has played nice with her nearly 13 million followers.

But the “Queen of Talk” is now showing that she is not one to be messed with. Last night Oprah was confronted by one of her followers, @Awalkdatalk, claiming that she does not give back to the ghettos in America. “@Oprah when are u going 2 give back 2 the ghettos in america?” he tweeted.

Oprah then snapped back “@awalkdatalk when are u? I’ve put 500 African American men thru college . And u sir?”

Oprah’s response received thousands of retweets and within moments became a viral sensation.

For the record, Oprah is the largest individual donor to the all-male HBCU, Morehouse College, reportedly donating more than $12 million since 1989.

During The Oprah Winfrey Show farewell spectacular in May 2011, two hundred Morehouse students that had benefited from Oprah’s generosity marched with candles and surrounded her on stage.

Aside from her charitable giving to Morehouse College, Oprah opened a school for girls in South Africa in 2007, and has donated millions of dollars to impoverished individuals around the world through her Angel Network.

Follow Chris Witherspoon on Twitter at @WitherspoonC