CHARLOTTE, N.C. (AP) — Cam Newton broke Peyton Manning’s rookie record for yards passing in a season and set a franchise record with a 91-yard touchdown pass to Brandon LaFell as the Panthers handed the Bucs their ninth straight defeat, 48-16 on Saturday.

Newton threw for 171 yards and three touchdowns and scored on a remarkable 49-yard run up the middle in which he outraced smaller defensive backs to the end zone.

The Panthers (6-9) scored on eight of their first nine possessions and piled up 397 yards in three quarters against the league’s 30th-ranked defense. Coach Ron Rivera pulled Newton and the other key starters early in the fourth quarter.

DeAngelo Williams scored on runs of 8 and 22 yards, his sixth and seventh of the season, and Jonathan Stewart ran for 88 yards and caught an 11-yard touchdown pass from Newton.

Copyright 2011 The Associated Press.